H1N1 G158E and D225G Low Reactors Recombine in Russia. -- (Recombinomics)
The above comments from the WHO report on the selection of 2010/2011 vaccine targets acknowledge the detection of low reactors but provide little detail. Recently released sequences at GISAID by the CDC and Mill Hill provide some specifics. Both detail isolates from Germany that have N158E as the only non-synonymous HA change, and both isolates are designated as low reactors. ...The combination of two low reactor polymorphism, N158E and D225G in the same HA sequence is cause for concern.