H1N1 Low Reactors Raise Vaccine Selection Concerns. -- (Recombinomics)
....However, the data from Mill Hill coupled with increasing numbers of sequences with D225G and D225N, especially since the vast majority of isolates were from fatal cases. Moreover these increases were from collections in 2009 and emerging sequences post-fall peak may have D225G/N with additional changes leading to further reductions in titers.
....The WHO report failed to directly address these low reactor examples and concerns that the sequences selected for 2010/2011 will have limited activity against emerging sequences with D225G and D225N.
More information on the testing of samples with D225G and D225N would be useful.