H1N1 D225G D225N H274Y Mixtures in Duke Death Cluster. -- (Recombinomics)
These data raise concerns that the levels of D225G/N and H274Y in the sequence databases under-represents these polymorphism in patients. Moreover, host factors, including immunological status may influence which sequences become dominant to impact the clinical picture.
The low reactor status published by Mill Hill raises concerns that immune response to wild type may select these variants, leading to more severe and fatal cases in the new wave which is beginning to emerge in the northern hemisphere.
Detailed sequence data on recent H1N1 is schools and hospitals in North Carolina would be useful.