30/12/2009

H1N1 Tamiflu Resistance Lesson Not Learned. -- (Recombinomics)

 

....H274Y in seasonal H1N1 went from 0% to 100% in one season in several countries.....

....H274Y jumped from one seasonal flu genetic background to another via recombination, as did severall additional polymorphism which jumped from clade 2C to clade 2B to create the strain that emerged in 2008.... 

.....The repeat in pandemic H1N1 may be much quicker because the widespread use of Tamiflu creates additional selection pressure for H274Y to pair with receptor binding domain changes that also drive selection.......

......The repeat in pandemic H1N1 may be much quicker because the widespread use of Tamiflu creates additional selection pressure for H274Y to pair with receptor binding domain changes that also drive selection........along with an explosion in the detection of H274Y worldwide, suggest that the fixing of H274Y may be well on its way in the next wave, which may begin in the upcoming weeks........

.....Thus, the potential for H274Y to become fixed in the next wave is quite real because competing seasonal flu strains are not circulating, and competing swine H1N1 that is Tamiflu sensitive is on the decline......

.....However, not only can swine H1N1 fill the upcoming void with H274Y, there are additional signs that receptor binding domain changes at position 225 are also emerging.  Mill Hill has reported H1N1 with D225G as a low reactor, signaling a selective immunological advantage over wild type.  Both D225G and D225N have been associated with severe and fatal cases, so the emergence of swine H1N1 with H274Y and D225G/N could be catastrophic.....

H1N1 Tamiflu Resistance Lesson Not Learned

22:04 Écrit par Dr MSFV | Lien permanent | Commentaires (0) |  Facebook |

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