23/12/2009

Emergence and Evolution of Pandemic Tamiflu Resistance. -- (Recombinomics)

 

However, the multiple examples of clustering of H274Y in a series of pandemic H1N1 sub-clades demonstrates that H274Y in pandemic H1N1 is following the same path as H274Y in seasonal flu.  It has appeared on multiple pandemic H1N1 sub-clades and has also paired up wuth two receptor binding domain changes, D225E and D225G.......

Thus, the evolution of H274Y in pandemic H1N1 is following the same path as H1N1 in seasonal flu, which involves H274Y jumping to multiple sub-clades via recombination, leading to an emerging sub-clade with H274Y and receptor binding domain changes....

 

Emergence and Evolution of Pandemic Tamiflu Resistance

13:31 Écrit par Dr MSFV | Lien permanent | Commentaires (0) |  Facebook |

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