Widespread Transmission of H1N1 Tamiflu Resistance. -- (Recombinomics).
One example involves sequences which have H274Y and D225E, This combination of Tamiflu resistance with a receptor binding domain change is of concern because prior fixing of Adamantane resistance, S31N, in seasonal H3N2, and Tamiflu resistance in seasonal H1N1 involved receptor binding domain changes.....;
This clustering of H274Y in multiple members of the same sub-clade support widespread transmission of H274Y in selected sub-clades leading to the emergence of H274Y via hitchhiking and recombination, as was seen in the fixing of H274Y in seasonal H1N1....;
The recent explosion of H274Y indicates this fixing is developing rapidly.