22/12/2009

Widespread Transmission of H1N1 Tamiflu Resistance. -- (Recombinomics).

 

One example involves sequences which have H274Y and D225E,  This combination of Tamiflu resistance with a receptor binding domain change is of concern because prior fixing of Adamantane resistance, S31N, in seasonal H3N2, and Tamiflu resistance in seasonal H1N1 involved receptor binding domain changes.....;

This clustering of H274Y in multiple members of the same sub-clade support widespread transmission of H274Y in selected sub-clades leading to the emergence of H274Y via hitchhiking and recombination, as was seen in the fixing of H274Y in seasonal H1N1....;

The recent explosion of H274Y indicates this fixing is developing rapidly.

Widespread Transmission of H1N1 Tamiflu Resistance

11:16 Écrit par Dr MSFV | Lien permanent | Commentaires (0) |  Facebook |

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