German H1N1Tamiflu Resistance Cluster Raises Concerns. -- (Recombinomics)
In one of these clusters, the H274Y is associated with D225E, raising concerns linkage between H274Y and receptor binding domain changes. In another cluster, one isolate has D225G paired up with H274Y, raising concerns that H274Y could be paired with RBD changes linked to fatal or more severe cases.
Thus, the two cases in Germany suggest H274Y is widespread and transmitting, and in some circumstances, the widespread appearance of H274Y may be linked to receptor binding domain changes