15/12/2009

Rapid H1N1 Evolution in Beijing Raises Concerns. -- (Recombinomics)

 

The Beijing Institute for Microbiology and Epidemiology has released sequences from a recent isolates collected in Beijing.in November...

Several of these polymorphisms were non-synonymous and signaled rapid evolution of the HA gene.......

The large number of changes, and the combinations of shared polymorphisms, suggest significant recombination and rapid evolution, which may be heralding a new wave......

Two of the non-synonymous polymorphisms (S131P and A337T) were in all three isolates (A/ Beijing/718 /2009. A/ Beijing/720 /2009, A/ Beijing/721 /2009). Three were in 720 and 721 (T314P, L322M, S327F).  One was in 718 and 720 (S330Y).  Unique changes were in 718 (A319T), 720 (L5R), 721 (T320S, G342E, Y354F)......

Full sequences on all eight isolates would be useful, as would more timely release of sequences from other countries.......

Rapid H1N1 Evolution in Beijing Raises Concerns

18:49 Écrit par Dr MSFV | Lien permanent | Commentaires (0) |  Facebook |

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