Explosion of Swine Flu Tamiflu Resistance in the United States. -- (Recombinomics)
Although Roche and others have maintained that the H274Y was due to a spontaneous mutation, there is little evidence to support this interpretation. Like seasonal H1N1, all resistance involved the same genetic change which coded for H274Y. Moreover, the rapid appearance of H274Y indicated it was not due to a spontaneous de novo mutation, but was circulating as a minor species which was more easily detected after Tamiflu treatment.
The more easily detected H274Y was described for seasonal flu and the appearance on multiple genetic backgrounds suggested the movement form one genetic background to another was due to recombination
Release of sequences from these recent cases would be useful to determine if a dominant H274Y species is emerging.