Ukraine Dead Increase to 328 - Still No Sequences. -- (Recombinomics)
WHO came out with a situation update which provided little specific information beyond earlier reports that the H1N1 did not have large changes. However, the new update did indicate that WHO regional centers in London and Atlanta were still investigating isolates, suggesting there have been sequences changes that are not fully characterized.......Recently released swine H1N1 from other locations have included receptor binding domain changes at position 225 (D225E, D225N, D225G) as well as 226 (Q226R) raising concerns that similar changes in Ukraine cold lead to the high frequency of fatal lung infections (Q226R has been seen previously in human H5N1 as well as H3 isolates from swine, ducks, and seals). The new update did not address receptor binding domain changes or other SNPs that could have significant effects on the pathogenicity of the virus.